Cytoskeletal Organization: Whirling to the Beat

Cytoskeletal Organization: Whirling to the Beat

Dense populations of microtubules driven by axonemal dynein form large vortices, providing insights into how simple interactions between individuals can give rise to large-scale coordinated movement, such as that seen in schools of fish and flocks of birds.

Cytoskeletal self-organization in neuromorphogenesis

Self-organization of dynamic microtubules via interactions with associated motors plays a critical role in spindle formation. The microtubule-based mechanisms underlying other aspects of cellular morphogenesis, such as the formation and development of protrusions from neuronal cells is less well understood. In a recent study, we investigated the molecular mechanism that underlies the massive re...

Cytoskeletal organization at the postsynaptic complex

Postsynaptic densities and the adjacent cytoskeleton were examined in deep-etched, unfixed slices of guinea pig anteroventral cochlear nucleus. The postsynaptic density seen in conventional thin sections corresponds to a meshwork of 4-nm filaments associated with intramembrane particles at the postsynaptic active zone of inhibitory as well as excitatory synapses. These filaments intermesh with ...

Hierarchical self-organization of cytoskeletal active networks.

The structural reorganization of the actin cytoskeleton is facilitated through the action of motor proteins that crosslink the actin filaments and transport them relative to each other. Here, we present a combined experimental-computational study that probes the dynamic evolution of mixtures of actin filaments and clusters of myosin motors. While on small spatial and temporal scales the system ...

Cytoskeletal Organization and Rb Tumor Suppressor Gene